Evi Soutoglou

Fellowship 2015

ARCHIVE

Evi Soutoglou obtained her PhD in the Institute of Molecular Biology and Biotechnology (IMBB), Crete, Greece, in tissue regulation of gene expression. She then held the postdoctoral positions at the IGBMC in Strasbourg and at National Cancer Institute, NIH, in Bethesda USA, supported by the EMBO long term and HFSP post doctoral fellowships. During this time, she studied the impact of nuclear architecture on the formation of chromosomal translocations. In 2009, she joined IGBMC as a group leader and CNRS researcher, supported by the prestigious ATIP program. In 2010, she obtained her Habilitation à Diriger les Recherches from the University of Strasbourg. In 2014,  she received the CNRS Bronze Medal. Her laboratory investigates the balance of DNA repair pathways in relation chromatin structure and nuclear architecture and its impact in the formation of chromosomal translocations.

The role of 3D genome organization in DNA repair

Post-doc: Alkmini Kalousi

The integrity of our genome is constantly challenged by various assaults leading to DNA lesions that may cause mutations and chromosomal rearrangements. DNA repair occurs in the highly compartmentalized nucleus. Recent literature provides some evidence that nonrandom global genome organization is a key factor in genome maintenance. We want o understand the functional relationship between DNA repair efficiency and previously defined 3D-topological maps of distinct chromatin domains. To this end, we will use two complementary approaches to induce and map DNA breaks in human and mouse genomes and evaluate how these are sensed and repaired over time and to determine whether DNA repair efficiency and robustness is related to specific 3D genomic locations of DNA lesions. Greater knowledge of the role of 3D genome organization in regulating DNA repair efficiency and pathway choice will reveal the regions of the genome that are susceptible to genomic instability.