Jianying Yang

Fellowship 2013

ARCHIVE

Dr. Jianying YANG studied Bioscience and Biotechnology at Zhejiang University in China. After obtaining his Ph.D. from Shanghai Institute of Biochemistry, he pursued his postdoctoral research with Prof. Roy Mariuzza at CARB (Center for Advanced Research in Biotechnology, University of Maryland, USA), to study the affinity maturation and intramolecular cooperativity in protein-protein interaction using structural biology and biophysical approaches. In 2003, he moved to Germany to work with Prof. Michael Reth at Max Planck Institute of Immunobiology and Epigenetics (MPI-IE, Freiburg, Germany), to study the organization of B cell receptor. Since 2010, he is a project leader in the Department of Molecular immunology at MPI-IE, and an associate member of Centre for Biological Signalling Studies (Bioss) of the University of Freiburg. Research of the group of Dr. Jianying YANG is currently focusing on deciphering the BCR signaling, by developing novel synthetic biology tools. With intensive national and international collaborations, the group is also applying advanced imaging techniques to study the dynamics and regulation of BCR oligomers and BCR-coreceptor interaction on cell surface.

In vivo visualizing the dynamics of cytokine-targeting cells

Fellows Fribourg-Strasbourg: Mei Li and Jianying Yang
Post-docs: John Lindner and Simone Reipschläger

The current FRIAS-USIAS project joins forces of the group of Dr. Mei LI (mouse modeling systems for cytokine functional study) at IGBMC, and the group of Dr. Jianying YANG (synthetic biology toolkit and advanced imaging technologies for membrane protein signaling study) at MPI-IE, in order to conduct a highly original research for better understanding the in vivo signaling of cytokine TSLP (thymic stromal lymphopoietin), a key player involved in multiple disease states including atopic diseases (e.g. atopic dermatitis and asthma). The research aims at developing a novel research concept of visualizing the dynamics of cytokine-targeting cells in tissue microenvironment, by employing innovative analysis strategies and methodological frameworks that combine the advanced microscopy and imaging technologies, synthetic biology toolkit, aptamer-based sensors, and mouse modeling and genetic tools. The study is expected to break a new interdisciplinary research ground in cytokine biology, cell signaling and in vivo imaging, and to provide powerful tools for research and medical application.