Université de Strasbourg

Georg Stoecklin

Chair of RNA Biology (2023-2024)

Georg StoecklinGeorg Stoecklin is professor for biochemistry at Heidelberg University, Germany. He earned an MD and PhD in Biology at the University of Basel, Switzerland. Following postdoctoral training at the Brigham and Women’s Hospital / Harvard Medical School in Boston, USA, he became junior group leader at the German Cancer Research Center in Heidelberg. Since 2016, he heads the Division of Biochemistry at the Medical Faculty Mannheim of Heidelberg University. He is also director of the Faculty Core Technology Platform and co-director of the Mannheim Institute of Innate Immunoscience.

Throughout his career, Georg Stoecklin has explored mechanisms controlling mammalian gene expression at the posttranscriptional level. He discovered cis-acting RNA elements that cause rapid mRNA decay, identified trans-acting RNA-binding proteins that recognize such regulatory elements, and characterized their interaction with the Ccr4-Not ribonuclease complex, which targets mRNAs for deadenylation and subsequent degradation. He further investigates mechanisms that control global mRNA turnover, and explores the regulation of mRNA translation into proteins. Current projects in the lab focus on elucidating the role of novel subunits of the Ccr4-Not complex, delineating mechanisms that control mRNA translation during macrophage activation, exploring translational control and stress granule formation upon virus infection, investigating pathways that connect cell proliferation with protein synthesis, examining links between ribosomal quality control and ribosome biogenesis, and understanding how splicing of immediate early genes is activated. To this end, the lab integrates a range of methods including biochemistry, molecular and cell biology, as well as next generation sequencing combined with bioinformatics approaches.

During his time in Strasbourg as USIAS associated chair, Georg Stoecklin is hosted by Dr. Bertrand Séraphin at the Institute of Genetics and Molecular and Cellular Biology (IGBMC) of the University of Strasbourg.

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