Université de Strasbourg

Chair of Immunology Lecture: Stem cell transplantation in autoimmune diseases

April 29, 2019
From 10:00 until 12:00


By Dr. Kentaro Akiyama

Senior Assistant Professor
Department of Oral Rehabilitation and Regenerative Medicine,
Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Okayama University, Japan

Salle de conférence, ISIS
8 rue Gaspard Monge, Strasbourg (Esplanade) (acces)

Poster

hosted by Professor Sylviane Muller, Chair of Therapeutic Immunology at USIAS
Organised jointly with UMR 7242: Biotechnology and cell signaling (BSC)

The therapeutic mechanism of mesenchymal stem cell transplantation in autoimmune diseases

Kentaro AkiyamaMesenchymal stem cells (MSCs) are a heterogeneous cell population, which can self-renew and can also differentiate into different lineages. They display important regulation roles in both adaptive and innate immune responses. Nowadays, MSCs are widely used in clinical trials as immunsuppressive agents for autoimmune and inflammatory diseases, including graft-versus-host disease, multiple sclerosis, systemic lupus erythematosus, chronic kidney diseases, and others.
Recent studies demonstrated that MSCs exert their immunomodulatory functions via secreting extracellular vesicles, which delivered parent cell cargo to recipient cells without oncogenicity or variability. It is also known that MSCs-induced immunotolerance involves soluble factors such as TGFbeta, IL-10 and others. At this stage, however, the detailed mechanisms that support MSCs immunomodulatory functions are not fully understood. In this lecture, Dr. Akiyama will show his findings with a focus on the therapeutic mechanisms exerted by MSCs through T cell apoptosis.

 

Stem cell transplantation Akiyama

 

 

 

 

 

 

 

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