Université de Strasbourg

Fabrice Jossinet

Fabrice Jossinet

Bioinformatician and molecular biologist, the research interests of Fabrice Jossinet are focused on the roles of ncRNAs in biological mechanisms and their structure-function relationship. He did his doctoral thesis in Chantal and Bernard Ehresmann group, where he focused on a better understanding of genomic RNA dimerization in HIV-1. In 2002, he joined the group of Eric Westhof as Assistant Professor in the unit UPR 9002. He became interested in the development of a new bioinformatics framework named Assemble2, dedicated to the study and construction of RNA architectures at the atomic level. This framework made possible the construction and publication of several high-resolution structures of ribosomes in collaboration with the groups of Roland Beckmann (Gene Center, Munich) and Joachim Franck (Columbia University, New York). These collaborative projects led to the publication of high-resolution structures for five eukaryotic organisms: Saccharomyces cerevisiae, Triticum aestivum, Trypanosoma brucei, Drosophila melanogaster and Homo sapiens. Since 2013, Fabrice Jossinet is leading a new team within the unit UPR 9002. Using the pathogenic yeast Candida glabrata as a model organism, this team combines bioinformatics and experimental approaches to better understand the role of ncRNAs in the development of diseases. In addition to being the second most common Candida pathogen after C. albicans, Candida glabrata has unique structural features in ncRNA families like RNase P or telomerase.

As part of his fellowship, Fabrice Jossinet is working on Transcriptional landscape of a CRISPR/Cas9 engineered yeast pathogen during infection.

Investissements d'Avenir