Université de Strasbourg

Ali Hamiche

Ali Hamiche After receiving my B.S. degree in Biochemistry from the University of Orsay (PARIS XI) in 1991, I spent the next five years in Dr. Ariel Prunell lab at the University of Paris 6, studying the structure of the nucleosome using biophysical and biochemical methods, and received my Ph.D. in Molecular and Cell Biology in 1995. I was hired in 1996 by the CNRS as a junior Staff Scientist in Helene Richard-Foy lab (Toulouse, France) where I started working on the role of chromatin structure in gene regulation. I continued to focus on chromatin research and enjoyed a 2 years (1998-2000) postdoctoral training with Dr. Carl Wu at NIH, where I discovered the mechanism of chromatin remodeling by the Drosophila NURF complex. I joined in 2003 Annick Harell Bellan Lab at the Andre Lwoff Institute in Villejuif (Paris) where I started developing proteomic techniques to analyze the role of the histone variant macroH2A in gene regulation. In 2008, I was hired as a group leader at IGBMC (Strasbourg, France) where I hold now a CNRS Director of Research position. My research is devoted to understanding the role of histone variants in epigenetic regulations and tumorigenesis. I have worked extensively on the isolation and purification of histone variant complexes and have studied their role by using the state of the art molecular and cell biology techniques. Among others, I have isolated and characterized the histone variant CENP-A deposition machineries and identified DAXX as a novel histone chaperone responsible for the replication-independent deposition of H3.3. More recently, I have identified ANP32E as a histone chaperone that removes H2AZ from promoters and provided the molecular basis for H2A.Z recognition and H2A.Z/H2B nucleosomal eviction by ANP32E. My work is funded by different French agencies. My team was rated A+ in the evaluation carried out by the AERES committee in 2008 and 2012. My group was recently recognized as an outstanding research group (Equipe labelisée) by the National Ligue against Cancer and awarded a five years grant (2014-2019). Recently, I received the prestigious Dandrimont-Bénicourt price from the French Academia of Sciences for my contribution to the epigenetic field and oncogenesis.

As part of his fellowship, Ali Hamiche is working on the project Mechanisms of CENP-A assembly and Propagation at Centromeres.

Investissements d'Avenir