Université de Strasbourg

Pierre Chambon

Chair of Molecular Genetics and Biology

Pierre ChambonPierre Chambon is Professor at the University of Strasbourg Institute for Advanced Study (USIAS), Honorary Professor at the Collège de France (Paris), and Emeritus Professor at the Faculty of Medicine of the University of Strasbourg . He is the founder and former Director of the Institute for Genetics and Cellular and Molecular Biology (IGBMC), and the founder and former Director of the Institut Clinique de la Souris (ICS/MCI), in Strasbourg, France.
Over the last 50 years, his scientific achievements are logically inscribed in an uninterrupted series of discoveries in the field of transcriptional control of gene expression in higher eukaryotes: discovery of PolyADPribose (1963), discovery of multiple RNA polymerases (1969), major contribution to the elucidation of chromatin structure, the Nucleosome (1974), discovery of animal split genes (1977), discovery of multiple promoter elements and their cognate factors (1980-1993) and of transcriptional enhancers (1981).

During the last 30 years his studies on the structure and function of nuclear receptors have changed our concept of signal transduction and endocrinology. By cloning the estrogen and progesterone receptors, and discovering the retinoic acid receptor family, Pierre Chambon markedly contributed to the discovery of the superfamily of nuclear receptors, and to the elucidation of their universal mechanism of action that links transcription, physiology and pathology. Through extensive site-directed mutagenesis and genetic studies in the mouse, Pierre Chambon unveiled the paramount importance of nuclear receptor signaling in embryonic development and homeostasis at the adult stage. These discoveries have revolutionized the fields of development, endocrinology and metabolism, and their disorders, pointing to new tactics for drug discovery, and finding important applications in biotechnology and modern medicine.

Pierre Chambon, author of more than 900 publications, has been ranked fourth among most prominent life scientist during the 1983-2002 period. He has received numerous international awards, including the CNRS Médaille d’Or (1979), the Louisa Gross Horwitz Prize for Biology and Biochemistry (1999), the March of Dimes Prize in Developmental Biology (2003), the Lasker Basic Medical Research Award (2004) and the Gairdner Foundation International Award (2010). He is a Member of the French Académie des Sciences, and a Member of the National Academy of Sciences (USA), the Royal Swedish Academy of Sciences, the Academia Europaea, the Academie Royale de Médecine of Belgium, and the Chinese Society of Genetics, and is also Doctor Honoris causa at several Universities. Pierre Chambon is Commandeur de la Légion d’Honneur and Grand Officier de l’Ordre National du Mérite.

Investissements d'Avenir